Language
English
Publication Date
10-15-2022
Journal
The American Journal of Cardiology
DOI
10.1016/j.amjcard.2022.06.060
PMID
35999068
PMCID
PMC11600339
PubMedCentral® Posted Date
11-27-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
The aim of this secondary analysis of The Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT) was to determine longitudinal changes over 24-months in skeletal thigh muscle volumes and individual muscle compartments in peripheral artery disease (PAD) patients with and without diabetes. A total of 48 patients with available magnetic resonance imaging (MRI) of the distal superficial femoral artery (SFA) at baseline and 2-years were included in this analysis. Muscle volumes and SFA wall, lumen, and total vessel volumes were quantified. Intra-reader reproducibility of muscle tracings was assessed with the intraclass correlation coefficient (ICC) using a 2-way model. Baseline characteristics were similar between non-diabetic and diabetic PAD patients, except for smoking history (p=0.049), cholesterol levels (p< 0.050), and calf walking pain (p=0.049). Inter-observer reproducibility of the muscle volume tracings was excellent for all muscle groups (all ICCs >0.86, confidence interval 0.69, 0.94). Total muscle and total leg volumes increased significantly between baseline and 24-months among non-diabetic PAD patients (31±6.4 cm3 vs. 32±7.0 cm3, p< 0.001; 18±4.4 cm3 vs. 19±4.8 cm3, p= 0.045), whereas there was no change in diabetic PAD patients. Total muscle volume was inversely associated with age and body mass index (BMI) in both diabetic and non-diabetic PAD patients (p< 0.05). In conclusion, MRI-quantified thigh muscle volumes are highly reproducible and may be of interest in assessing diabetic and non-diabetic PAD patients.
Keywords
Diabetes Mellitus, Humans, Magnetic Resonance Imaging, Muscle, Skeletal, Peripheral Arterial Disease, Reproducibility of Results, Thigh, Peripheral artery disease, magnetic resonance imaging, skeletal muscle volumes, diabetes mellitus
Published Open-Access
yes
Recommended Citation
Gimnich, Olga A; Ortiz, Carlos B; Yang, Eric Y; et al., "Comparison of Longitudinal Skeletal Thigh Muscle Findings With Magnetic Resonance Imaging in Patients With Peripheral Artery Disease With-Versus-Without Diabetes Mellitus" (2022). Faculty and Staff Publications. 4147.
https://digitalcommons.library.tmc.edu/baylor_docs/4147