Language
English
Publication Date
12-1-2023
Journal
Topics in Magnetic Resonance Imaging
DOI
10.1097/RMR.0000000000000309
PMID
38051028
PMCID
PMC11742609
PubMedCentral® Posted Date
1-19-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Background: Longitudinal associations of noninvasive 2-dimensional phase-contrast magnetic resonance imaging (2D-PC-MRI) velocity markers of the superficial femoral artery (SFA) were analyzed along with the characteristics of peripheral artery disease (PAD). We hypothesized that the 2-year differences in MRI-based measures of SFA velocity were associated with longitudinal changes in markers of PAD.
Methods: A total of 33 (11 diabetic, 22 nondiabetic) patients with PAD with baseline and 2-year follow-up MRI scans were included in this secondary analysis of the Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT). Electrocardiographically gated 2D-PC-MRI was performed at a proximal and a distal location of the distal SFA territory. SFA lumen, wall, and total vessel volumes and the normalized wall index (NWI) were analyzed.
Results: Baseline characteristics did not differ between diabetic and nondiabetic PAD patients. Maximum proximal and distal SFA velocity measures did not differ between baseline and 2 years (41.98 interquartile range (IQR) (23.58-72.6) cm/s vs. 40.31 IQR (26.69-61.29) cm/s; P = 0.30). Pooled analysis (N = 33) showed that the 24-month change in the NWI was inversely associated with the 24-month change in the proximal maximal SFA velocity (beta = -168.36, R2 = 0.150, P value = 0.03). The 24-month change of the maximum velocity differences between the proximal and distal SFA locations was inversely associated with the 24-month changes in peak walking distance (beta = -0.003, R2 = 0.360, P value = 0.011).
Conclusion: The 2-year change of SFA plaque burden is inversely associated with the 2-year change of proximal peak SFA blood flow velocity. 2D-PC-MRI measured SFA velocity may be of interest in assessing PAD longitudinally.
Keywords
Humans, Diabetes Mellitus, Femoral Artery, Magnetic Resonance Imaging, Peripheral Arterial Disease, Plaque, Atherosclerotic, Treatment Outcome, Peripheral artery disease, magnetic resonance imaging, diabetes mellitus, atherosclerosis, superficial femoral artery, arterial blood flow velocity
Published Open-Access
yes
Recommended Citation
Sinharoy, Ankita; Reddy, Neeti; Lin, John Kent; et al., "Longitudinal Magnetic Resonance Imaging-Based Superficial Femoral Artery Velocity Measurements in Diabetic and Nondiabetic Patients With Peripheral Artery Disease" (2023). Faculty and Staff Publications. 4155.
https://digitalcommons.library.tmc.edu/baylor_docs/4155