Language
English
Publication Date
3-19-2024
Journal
Journal of the American Heart Association
DOI
10.1161/JAHA.123.031607
PMID
38471823
PMCID
PMC11010020
PubMedCentral® Posted Date
3-12-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Background: It is unclear how metabolic syndrome (MetS) and diabetes affect Gal-3 (galectin 3) levels and the resulting implications for heart failure (HF) risk. We assessed relationships of MetS and diabetes with Gal-3, and their joint associations with incident HF.
Methods and results: We included 8445 participants without HF (mean age, 63 years; 59% men; 16% Black race) at ARIC (Atherosclerosis Risk in Communities) study visit 4 (1996-1999). We categorized participants as having MetS only, MetS with diabetes, or neither, and by quartiles of MetS severity Z score. We assessed cross-sectional associations of metabolic risk categories with high Gal-3 level (≥75th percentile) using logistic regression. We used Cox regression to evaluate combined associations of metabolic risk categories and Gal-3 quartiles with HF. In cross-sectional analyses, compared with no MetS and no diabetes, MetS only (odds ratio [OR], 1.24 [95% CI, 1.10-1.41]) and MetS with diabetes (OR, 1.59 [95% CI, 1.32-1.92]) were associated with elevated Gal-3. Over a median follow-up of 20.5 years, there were 1749 HF events. Compared with individuals with neither diabetes nor MetS and with Gal-3 in the lowest quartile, the combination of MetS with diabetes and Gal-3 ≥75th percentile was associated with a 4-fold higher HF risk (hazard ratio, 4.35 [95% CI, 3.30-5.73]). Gal-3 provided HF prognostic information above and beyond MetS, NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity cardiac troponin T, and CRP (C-reactive protein) (ΔC statistic for models with versus without Gal-3: 0.003; P=0.004).
Conclusions: MetS and diabetes are associated with elevated Gal-3. The HF risk significantly increased with the combination of greater metabolic risk and higher Gal-3.
Keywords
Female, Humans, Male, Middle Aged, Biomarkers, Cross-Sectional Studies, Diabetes Mellitus, Galectin 3, Heart Failure, Natriuretic Peptide, Brain, Peptide Fragments, Risk Factors, diabetes, galectin 3, heart failure, metabolic status, Diabetes, Type 2; Obesity; Epidemiology; Primary Prevention
Published Open-Access
yes
Recommended Citation
Echouffo-Tcheugui, Justin B; Zhang, Sui; Florido, Roberta; et al., "Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study" (2024). Faculty and Staff Publications. 4158.
https://digitalcommons.library.tmc.edu/baylor_docs/4158