Publication Date
1-1-2021
Journal
Frontiers in Medicine
DOI
10.3389/fmed.2021.745279
PMID
34646847
PMCID
PMC8502854
PubMedCentral® Posted Date
9-27-2021
PubMedCentral® Full Text Version
Post-print
Published Open-Access
no
Keywords
diabetic kidney disease, mitochondria, mitochondrial dynamics, oxidative phosphorylation, mitochondrial respiratory complexes, bioenergetics
Abstract
The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement on future targeted therapies based on improving mitochondrial function in DKD. This review will highlight the latest advances in understanding the nature of mitochondria dysfunction and its role in progression of DKD, and the development of mitochondrial targets that could be potentially used to prevent its progression.
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Biology Commons, Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Medical Sciences Commons, Nephrology Commons