Language
English
Publication Date
3-1-2024
Journal
Journal of Investigative Medicine
DOI
10.1177/10815589231225183
PMID
38148342
Abstract
Dysmetabolic states, such as type 2 diabetes (T2D), characterized by insulin resistance (IR), are associated with fatty liver, increased cardiovascular disease (CVD) risk, and decreased functional exercise capacity (FEC). Rosiglitazone (RO) improves exercise capacity and IR in T2D. However, the effects of RO on FEC and other markers of CVD risk in prediabetes are unknown. We hypothesized that insulin sensitization with RO would improve exercise capacity and markers of CVD risk in participants with impaired glucose tolerance (IGT). Exercise performance (peak oxygen consumption and oxygen uptake kinetics), IR (homeostasis model assessment of IR and quantitative insulin sensitivity check index), and surrogate cardiovascular endpoints (coronary artery calcium (CAC) volume and density and C-reactive protein (CRP)) were measured in participants with IGT after 12 and 18 months of RO or placebo (PL). RO did not significantly improve exercise capacity. Glycemic measures and IR were significantly lower in people on RO compared to PL at 18 months. CAC volume progression was not different between PL and RO groups. RO did not improve exercise capacity during an 18-month intervention despite improved IR and glycemia in people with IGT. Future studies should explore why effects on FEC with RO occur in T2D but not IGT. Understanding these questions may help in targeting therapeutic approaches in T2D and IGT.
Keywords
Humans, Insulin Resistance, Glucose Intolerance, Rosiglitazone, Diabetes Mellitus, Type 2, Exercise Tolerance, Glucose Tolerance Test, Blood Glucose, Cardiovascular Diseases, Impaired glucose tolerance, VO2, coronary calcium score, exercise, insulin sensitivity, prediabetes, thiazolidinedione
Published Open-Access
yes
Recommended Citation
Abushamat, Layla A; Schauer, Irene E; Low Wang, Cecilia C; et al., "Rosiglitazone Improves Insulin Resistance but Does Not Improve Exercise Capacity in Individuals With Impaired Glucose Tolerance: A Randomized Clinical Study" (2024). Faculty and Staff Publications. 4235.
https://digitalcommons.library.tmc.edu/baylor_docs/4235