Language
English
Publication Date
7-8-2025
Journal
NPJ Aging
DOI
10.1038/s41514-025-00244-x
PMID
40628762
PMCID
PMC12238350
PubMedCentral® Posted Date
7-8-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent.
Keywords
Senescence, Cell biology, Molecular biology
Published Open-Access
yes
Recommended Citation
Kato, Kosuke; Kleinhenz, Jennifer M; Shin, Yoon-Joo; et al., "Psilocybin Treatment Extends Cellular Lifespan and Improves Survival of Aged Mice" (2025). Faculty and Staff Publications. 4239.
https://digitalcommons.library.tmc.edu/baylor_docs/4239