Language
English
Publication Date
7-1-2024
Journal
Immunological Reviews
DOI
10.1111/imr.13338
PMID
38683173
PMCID
PMC11262992
PubMedCentral® Posted Date
7-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
White adipose tissue (WAT) is a vital endocrine organ that regulates energy balance and metabolic homeostasis. In addition to fat cells, WAT harbors macrophages with distinct phenotypes that play crucial roles in immunity and metabolism. Nutrient demands cause macrophages to accumulate in WAT niches, where they remodel the microenvironment and produce beneficial or detrimental effects on systemic metabolism. Given the abundance of macrophages in WAT, this review summarizes the heterogeneity of WAT macrophages in physiological and pathological conditions, including their alterations in quantity, phenotypes, characteristics, and functions during WAT growth and development, as well as healthy or unhealthy expansion. We will discuss the interactions of macrophages with other cell partners in WAT including adipose stem cells, adipocytes, and T cells in the context of various microenvironment niches in lean or obese condition. Finally, we highlight how adipose tissue macrophages merge immunity and metabolic changes to govern energy balance for the organism.
Keywords
Humans, Macrophages, Adipose Tissue, White, Animals, Energy Metabolism, Obesity, Adipocytes, Homeostasis, white adipose tissue, macrophage, obesity, immunity, metabolism
Published Open-Access
yes
Recommended Citation
Wang, Qun; Hartig, Sean M; Ballantyne, Christie M; et al., "The Multifaceted Life of Macrophages in White Adipose Tissue: Immune Shift Couples With Metabolic Switch" (2024). Faculty and Staff Publications. 4247.
https://digitalcommons.library.tmc.edu/baylor_docs/4247