Language
English
Publication Date
8-23-2023
DOI
10.3390/biomedicines11092345
PMID
37760786
PMCID
PMC10525596
PubMedCentral® Posted Date
8-23-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Clot retraction results from retractions of platelet filopodia and fibrin fibers and requires the functional platelet αIIbβ3 integrin. This assay is widely used to test the functions of platelets and fibrinogen as well as the efficacy of fibrinolysis. Changes in clot retraction have been found in a variety of hemostatic abnormalities and, more recently, in arterial thrombosis. Despite its broad clinical use and low cost, many aspects of clot retraction are poorly understood. In the present study, we performed two clinical standard clot retraction assays using whole-blood and platelet-rich plasma (PRP) samples to determine how clot retraction correlates with platelet counts and mean volume, the density of αIIbβ3 integrin and PLA genotypes, and plasma fibrinogen levels. We found that clot retraction was affected by platelet counts, but not mean platelet volume. It correlated with the surface density of the integrin αIibβ3, but not PLA genotypes. These results indicate that clot retraction measures a unique aspect of platelet function and can serve as an additional means to detect functional changes in platelets.
Keywords
clot retraction, integrin αIibβ3, PLA genotypes
Published Open-Access
yes
Recommended Citation
Gao, Daniel; Sun, Caroline W; Woodley, Angela B; et al., "Clot Retraction and Its Correlation with the Function of Platelet Integrin α" (2023). Faculty and Staff Publications. 4259.
https://digitalcommons.library.tmc.edu/baylor_docs/4259