Language
English
Publication Date
1-1-2024
DOI
10.1016/j.jacl.2024.08.013
PMID
39256087
PMCID
PMC11734832
PubMedCentral® Posted Date
9-5-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
This National Lipid Association (NLA) Expert Clinical Consensus provides an overview of the physiologic and clinical considerations regarding the role of apolipoprotein B (apoB) measurement to guide clinical care based on the available scientific evidence and expert opinion. ApoB represents the total concentration of atherogenic lipoprotein particles in the circulation and more accurately reflects the atherogenic burden of lipoproteins when compared to low-density lipoprotein cholesterol (LDL-C). ApoB is a validated clinical measurement that augments the information found in a standard lipoprotein lipid panel; therefore, there is clinical value in using apoB in conjunction with a standard lipoprotein lipid profile when assessing risk and managing lipid-lowering therapy (LLT). ApoB has been shown to be superior to LDL-C in risk assessment both before and during treatment with LLT. In individuals, there can be discordance between levels of LDL-C and apoB, as well as LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C), despite high levels of population-wide correlation. When there is discordance between LDL-C and apoB, or LDL-C and non-HDL-C, atherosclerotic cardiovascular disease risk generally aligns better with apoB or non-HDL-C. Additionally, apoB can be used in tandem with standard lipoprotein lipid measurements to diagnose distinct lipoprotein phenotypes. ApoB testing can inform clinical prognosis and care, as well as enable family cascade screening, when an inherited lipoprotein syndrome is identified. The NLA and other organizations will continue to educate clinicians about the role of apoB measurement in improving clinical risk assessment and dyslipidemia management. An urgent need exists to improve access and reimbursement for apoB testing.
Keywords
Adult, Humans, Apolipoproteins B, Cardiovascular Diseases, Cholesterol, LDL, Consensus, Heart Disease Risk Factors, Risk Assessment, Apolipoprotein B, atherosclerosis, discordance, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol
Published Open-Access
yes
Recommended Citation
Soffer, Daniel E; Marston, Nicholas A; Maki, Kevin C; et al., "Role of Apolipoprotein B in the Clinical Management of Cardiovascular Risk in Adults: An Expert Clinical Consensus From the National Lipid Association" (2024). Faculty and Staff Publications. 4283.
https://digitalcommons.library.tmc.edu/baylor_docs/4283