Language

English

Publication Date

11-29-2023

Journal

Journal of Clinical Medicine

DOI

10.3390/jcm12237400

PMID

38068452

PMCID

PMC10706980

PubMedCentral® Posted Date

11-29-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD.

Keywords

gastroesophageal reflux disease (GERD), cardiovascular disease (CVD), coronary artery disease (CAD), atherosclerosis, myocardial infarction (MI), proton pump inhibitor (PPI)

Published Open-Access

yes

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