Language
English
Publication Date
1-1-2023
Journal
ACG Case Reports Journal
DOI
10.14309/crj.0000000000000954
PMID
38445216
PMCID
PMC10914231
PubMedCentral® Posted Date
1-27-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Pancreatic neuroendocrine tumors are rare neoplasms characterized into nonfunctioning (NF-PNET) and functioning (F-PNET) subtypes. F-PNETs typically involve overt symptoms related to excessive hormone secretion but may rarely present first as NF-PNETs with delayed transformation. We present a patient with known NF-PNET with liver metastases who developed hypoglycemia 2 years after initial diagnosis due to malignant insulinoma. Hypoglycemia was refractory to continuous dextrose but improved temporarily after diazoxide and hepatic artery embolization. Malignant insulinomas are usually metastatic at presentation and portend poor prognosis. Hypoglycemia may be medically managed with steroids, somatostatin analogues, and diazoxide, along with therapies to reduce tumor burden.
Keywords
pancreatic neuroendocrine tumor, insulinoma, hepatic artery embolization, diazoxide, liver metastases
Published Open-Access
yes
Recommended Citation
Chatterjee, Ritodhi; Ali, Basim; Nguyen, Son H; et al., "Malignant Insulinoma Arising From Nonfunctioning Pancreatic Neuroendocrine Tumor" (2023). Faculty and Staff Publications. 4347.
https://digitalcommons.library.tmc.edu/baylor_docs/4347