Language
English
Publication Date
1-18-2024
DOI
10.1210/clinem/dgad415
PMID
37440585
PMCID
PMC10795939
PubMedCentral® Posted Date
7-13-2023
PubMedCentral® Full Text Version
Post-print
Abstract
Skeletal fracture has recently emerged as a complication of obesity. Given the normal or better than normal bone mineral density (BMD), the skeletal fragility of these patients appears to be a problem of bone quality rather than quantity. Type 2 diabetes mellitus (T2DM), the incidence of which increases with increasing body mass index, is also associated with an increased risk for fractures despite a normal or high BMD. With the additional bone pathology from diabetes itself, patients with both obesity and T2DM could have a worse skeletal profile. Clinically, however, there are no available methods for identifying those who are at higher risk for fractures or preventing fractures in this subgroup of patients. Weight loss, which is the cornerstone in the management of obesity (with or without T2DM), is also associated with an increased risk of bone loss. This review of the literature will focus on the skeletal manifestations associated with obesity, its interrelationship with the bone defects associated with T2DM, and the available approach to the bone health of patients suffering from obesity.
Keywords
Humans, Diabetes Mellitus, Type 2, Bone Density, Fractures, Bone, Obesity, Bone and Bones, obesity, bone, type 2 diabetes mellitus, fractures, weight loss
Published Open-Access
yes
Recommended Citation
Rui Chen and Reina Armamento-Villareal, "Obesity and Skeletal Fragility" (2024). Faculty and Staff Publications. 4355.
https://digitalcommons.library.tmc.edu/baylor_docs/4355