Language
English
Publication Date
7-8-2025
Journal
Diabetes
DOI
10.2337/dbi25-0001
PMID
40627343
PMCID
PMC12418233
PubMedCentral® Posted Date
9-10-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
The primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep apnea, and atherosclerotic heart disease. However, it is also associated with a decline in lean mass and bone mineral density, which increases the risk of sarcopenia and osteoporosis. When performed alongside CR, progressive resistance training (RT) attenuates this loss of lean mass and bone mass, while the addition of aerobic training (AT) further improves cardiorespiratory fitness. The individual benefits of RT and AT are complementary, and combining both exercise training modalities during CR provides the most optimal benefits for body composition and physical function. The World Health Organization recommends that adults engage in at least 150 min of moderate-intensity or 75 min of vigorous-intensity AT weekly and participate in RT activities involving major muscle groups at least 2 days per week. While this recommendation applies to the general adult population, regular exercise training that incorporates both RT and AT is particularly crucial for adults with obesity undergoing weight loss interventions. This clinical perspective highlights the benefits of exercise training alongside current weight loss strategies, such as lifestyle changes, bariatric surgery, and pharmacotherapy, with a focus on incretin-based therapies.
Keywords
Aerobic Exercise, Bariatric Surgery Outcomes, Body Composition, Exercise Training, Incretin-based Therapy, Lifestyle Intervention, Obesity Treatment, Osteoporosis, Resistance Training, Sarcopenia, Weight Loss/Reduction, Weight Loss Maintenance
Published Open-Access
yes
Recommended Citation
Bryan C Jiang and Dennis T Villareal, "The Benefits of Exercise Training in Combination With Weight Loss Therapies" (2025). Faculty and Staff Publications. 4375.
https://digitalcommons.library.tmc.edu/baylor_docs/4375
Graphical Abstract