Language
English
Publication Date
10-24-2025
Journal
Journal of Hematology & Oncology
DOI
10.1186/s13045-025-01740-z
PMID
41137150
PMCID
PMC12551241
PubMedCentral® Posted Date
10-24-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) is a known risk factor for hematologic malignancies (HM), but its distribution and clinical implications across diverse ancestries remain poorly characterized. In this study, we investigated CHIP and its progression to HM in a large, racially diverse cohort from the All of Us Research Program, comprising 245,388 participants. We identified 10,446 CHIP driver mutations in 9,476 individuals. Our analysis revealed clear racial disparities in CHIP prevalence and mutational profiles: African American (AA) individuals had higher odds of CHIP and exhibited distinct mutation patterns compared to White American (WA) individuals. Consistent with prior studies, CHIP was associated with an increased risk of HM, particularly myeloid malignancies. Notably, ancestry influenced the subtype of myeloid malignancy observed; CHIP was more strongly linked to myeloproliferative neoplasms in AA individuals compared with WA individuals. These findings demonstrated significant racial differences in CHIP biology and HM progression, highlighting the need for ancestry-informed approaches to CHIP risk assessment and HM prevention.
Keywords
Humans, Hematologic Neoplasms, Clonal Hematopoiesis, Male, Female, Middle Aged, Mutation, White People, Black or African American, Aged, Adult, Cohort Studies, White, Clonal hematopoiesis of indeterminate potential, Racial disparity, Hematologic malignancies, All of Us research program
Published Open-Access
yes
Recommended Citation
Zijian Zhang and Chao Cheng, "Racial Disparities in Clonal Hematopoiesis and Their Impact on Hematologic Malignancies" (2025). Faculty and Staff Publications. 4404.
https://digitalcommons.library.tmc.edu/baylor_docs/4404