Language
English
Publication Date
4-1-2025
Journal
Clinical and Molecular Hepatology
DOI
10.3350/cmh.2024.0987
PMID
39610192
PMCID
PMC12016658
PubMedCentral® Posted Date
11-29-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Background/aims: Multi-society experts proposed the adoption of new terminology, metabolic dysfunctionassociated steatotic liver disease (MASLD) and steatotic liver disease (SLD). We studied the current prevalence of SLD and its subcategories in the US.
Methods: Using the recent National Health and Nutrition Examination Survey from 2017 to 2023, we analyzed data from 12,199 participants (≥18 years) who completed transient elastography. SLD and its subcategories, including MASLD, metabolic and alcohol-related liver disease (MetALD), and alcohol-related liver disease (ALD), were categorized according to consensus nomenclature.
Results: The age-adjusted prevalence of SLD (cut-off: 285 dB/m) was 35.0% (95% confidence interval [CI] 33.4-36.7). Within this category, the age-adjusted prevalence for MASLD was 31.9% (95% CI 30.4-33.4), MetALD 2.2% (95% CI 1.8-2.6), and ALD 0.8% (95% CI 0.6-1.1). The prevalence of SLD and MASLD showed a statistically insignificant decrease during COVID-19, while ALD increased without significance. In contrast, the prevalence of advanced fibrosis in SLD was significantly higher during the COVID-19 era, at 9.8% for 285 dB/m and 7.8% for 263 dB/m, compared to 7.4% (P=0.039) and 6% (P=0.041) in the pre-COVID-19 era. The proportion of advanced fibrosis and cirrhosis in individuals with ALD was two-fold higher than MASLD and MetALD, largely due to increases during the COVID-19 era.
Conclusion: While the prevalence of SLD and its subcategories remained stable, there was a significant increase in advanced fibrosis among SLD individuals during the COVID-19 era, with ALD having a proportion of advanced fibrosis and cirrhosis that was twice as high as MASLD and MetALD.
Keywords
Humans, United States, Male, Female, Middle Aged, Adult, Liver Cirrhosis, Prevalence, Nutrition Surveys, Fatty Liver, Aged, COVID-19, Elasticity Imaging Techniques, MASLD, NHANES, MetALD, Alcohol-related liver disease
Published Open-Access
yes
Recommended Citation
Kim, Donghee; Danpanichkul, Pojsakorn; Wijarnpreecha, Karn; et al., "Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017-2023" (2025). Faculty and Staff Publications. 4427.
https://digitalcommons.library.tmc.edu/baylor_docs/4427
Graphical Abstract