The Interaction Between Autophagy, Helicobacter pylori, and Gut Microbiota in Gastric Carcinogenesis
Language
English
Publication Date
10-1-2023
Journal
Trends in Microbiology
DOI
10.1016/j.tim.2023.04.001
PMID
37120362
PMCID
PMC10523907
PubMedCentral® Posted Date
10-1-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
Chronic infection with Helicobacter pylori is the primary risk factor for the development of gastric cancer. Hindering our ability to comprehend the precise role of autophagy during H. pylori infection is the complexity of context-dependent autophagy signaling pathways. Recent and ongoing progress in understanding H. pylori virulence allows new frontiers of research for the crosstalk between autophagy and H. pylori. Novel approaches toward discovering autophagy signaling networks have further revealed their critical influence on the structure of gut microbiota and the metabolome. Here we intend to present a holistic view of the perplexing role of autophagy in H. pylori pathogenesis and carcinogenesis. We also discuss the intermediate role of autophagy in H. pylori-mediated modification of gut inflammatory responses and microbiota structure.
Keywords
Humans, Helicobacter pylori, Gastrointestinal Microbiome, Stomach, Carcinogenesis, Stomach Neoplasms, Helicobacter Infections, Autophagy, anticancer therapy, autophagy, gastric cancer, gut microbiota, Helicobacter pylori
Published Open-Access
yes
Recommended Citation
Nabavi-Rad, Ali; Yadegar, Abbas; Sadeghi, Amir; et al., "The Interaction Between Autophagy, Helicobacter pylori, and Gut Microbiota in Gastric Carcinogenesis" (2023). Faculty and Staff Publications. 4446.
https://digitalcommons.library.tmc.edu/baylor_docs/4446