Language

English

Publication Date

4-15-2024

Journal

Dermatology Online Journal

DOI

10.5070/D330263591

PMID

38959931

Abstract

Chronic spontaneous urticaria (CSU) involves recurrent, pruritic wheals lasting more than 6 weeks in response to various etiologies, including unknown causality. Though most cutaneous reactions to the COVID-19 vaccine series are self-limited and of short duration, more complex presentations including chronic spontaneous urticaria have been described. To the best of our knowledge, this is the first report of chronic spontaneous urticaria following heterologous mRNA COVID-19 booster vaccination that includes vaccination with both forms of the mRNA vaccine. Our patient received Pfizer-BioNTech for the primary series and Moderna for the booster. After failing several therapies, our patient's urticaria was refractory even to omalizumab. The source for chronic spontaneous urticaria development in our patient may be related to the unique humoral response elicited by receipt of a different mRNA vaccine manufacturer.

Keywords

Humans, Chronic Urticaria, COVID-19 Vaccines, Immunization, Secondary, BNT162 Vaccine, Female, Omalizumab, COVID-19, Middle Aged, Male, Adult

Published Open-Access

yes

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