Language
English
Publication Date
11-1-2025
Journal
Cell Biochemistry & Function
DOI
10.1002/cbf.70138
PMID
41215534
Abstract
Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functions, it is well established that AD is associated with cardiovascular risk factors beyond only cerebral decline. In this study, we measured hemodynamic parameters related to cardiovascular and cerebrovascular function in 5xFAD mice with AD and their littermates. Specifically, we measured cardiovascular pulse wave velocity parameters, a marker of arterial stiffness and cardiovascular risk, and cerebrovascular pulse wave velocity, a novel technique to measure cerebral arterial stiffness. Our results showed that while 5xFAD mice exhibited significant differences in ejection time, pulse pressure, and Tei index, many other cardiovascular and cerebral parameters were not different. Despite reports that amyloid plaque deposition begins at an early age of 1.5 months in 5xFAD mice, our results did not indicate significant cardiovascular changes. Studies to elucidate cardiovascular and cerebrovascular parametric changes should be done at later ages where the underlying changes are more profound.
Keywords
5xFAD, alzheimer's disease, cardiovascular disease, pulse wave velocity
Published Open-Access
yes
Recommended Citation
Marshall, Andrea G; Stephens, Dominique; Neikirk, Kit; et al., "Alterations in Cardiovascular Parameters in 5xFAD Murine Model" (2025). Faculty and Staff Publications. 4483.
https://digitalcommons.library.tmc.edu/baylor_docs/4483