Language
English
Publication Date
1-1-2024
Journal
Current Problems in Cardiology
DOI
10.1016/j.cpcardiol.2023.102131
PMID
37866417
Abstract
Background: Reduction of diastolic blood pressure (DBP) below 70 mmHg may decrease perfusion to the heart and worsen cardiovascular (CV) outcomes.
Aims: Explore the association between low DBP and CV outcomes.
Methods: We searched the online databases until August 2023 for studies reporting the risk of all-cause mortality (ACM) or CV outcomes in patients with low versus normal DBP (70-80mm Hg).
Results: Inclusion of 10 studies (n = 1,998,223 patients) found that a mean achieved DBP < 60 mmHg was associated with an increased risk of all-cause mortality (HR 1.48; 95 % CI [1.26-1.74]), especially in patients with pre-existing CV disease. It was also associated to a higher risk of major adverse cardiovascular events (HR 1.84; [1.28-2.65]) and myocardial infarction (HR 1.49; [1.13-1.97]). A DBP of 60-69 mmHg was associated with an increased risk of all-cause mortality (HR 1.11; [1.03-1.20]).
Conclusion: Reduction of DBP, particularly below 60 mmHg, is associated with increased risk of ACM.
Keywords
Humans, Blood Pressure, Hypertension, Stroke, Myocardial Infarction, Heart Failure, Cardiovascular Diseases, All-Cause Mortality; Diastolic Blood Pressure; Ischemic Stroke; Major Adverse Cardiovascular Events; Myocardial Infarction
Published Open-Access
yes
Recommended Citation
Siddiqi, Tariq Jamal; Usman, Muhammad Shariq; Siddiqui, Amna; et al., "Association of Low Diastolic Blood Pressure With Cardiovascular Outcomes and All-Cause Mortality: A Meta-Analysis" (2024). Faculty and Staff Publications. 4486.
https://digitalcommons.library.tmc.edu/baylor_docs/4486