Language
English
Publication Date
11-13-2025
Journal
American Journal of Kidney Diseases
DOI
10.1053/j.ajkd.2025.07.020
PMID
41241128
Abstract
Detection and management of depression have special considerations in people with kidney disease. Screening should be done every 6-12 months using a self-reported questionnaire. Clinicians should rule out symptoms from medical conditions such as dialysis inadequacy or hypothyroidism and confirm the presence of sadness or anhedonia. Sertraline has shown limited efficacy and an increased risk for adverse effects such as gastrointestinal symptoms, so cautious, gradual dose titration is warranted. Cognitive behavioral therapy has potential benefit for depressive symptoms in people with kidney disease. Current trials are evaluating behavioral activation therapy. Physical activity has many benefits and likely improves depression.
Keywords
CBT, CKD, depression, kidney failure, sertraline
Published Open-Access
yes
Recommended Citation
Gregg, L Parker; Goodman, Lynnel; Carroll, Ella Q; et al., "A Practical Primer on How to Detect and Treat Depression in CKD" (2025). Faculty and Staff Publications. 4570.
https://digitalcommons.library.tmc.edu/baylor_docs/4570