Language
English
Publication Date
8-1-2025
Journal
ACG Case Reports Journal
DOI
10.14309/crj.0000000000001780
PMID
40757079
PMCID
PMC12316325
PubMedCentral® Posted Date
8-1-2025
PubMedCentral® Full Text Version
Post-print
Abstract
A 58-year-old woman with endometrial cancer started on paclitaxel in combination with carboplatin chemotherapy, presented to the hospital with severe anemia and melena. An esophagogastroduodenoscopy with biopsies revealed diffuse gastric antrum hemorrhagic gastropathy without inflammatory changes. She had recurrent admissions with similar presentations during her chemotherapy. Her management included frequent blood transfusions, endoscopic Argon plasma coagulation to hemorrhagic lesions, and a prolonged course of proton pump inhibition to facilitate post-Argon plasma coagulation mucosal healing. Weeks after completing chemotherapy, her hemoglobin improved and recurrent upper gastrointestinal bleeding resolved. In this case, we identify a rare paclitaxel, in combination with carboplatin, associated hemorrhagic gastropathy with symptomatic, clinical, and endoscopic resolution seen only after completing chemotherapy.
Keywords
hemorrhagic gastropathy, chemotherapy-induced gastritis, argon plasma coagulation, taxanes
Published Open-Access
yes
Recommended Citation
Kristeen Onyirioha and Maya Balakrishnan, "Hemorrhagic Gastropathy From Paclitaxel-Carboplatin Combination Chemotherapy" (2025). Faculty and Staff Publications. 4572.
https://digitalcommons.library.tmc.edu/baylor_docs/4572