Language
English
Publication Date
8-1-2023
Journal
American Journal of Transplantation
DOI
10.1016/j.ajt.2023.04.024
PMID
37116583
Abstract
Livers from donors with positive hepatitis B surface antigens (HBsAg+) have been used to expand the donor pool; however, outcome data are limited. We aim to evaluate survival following liver transplant (LT) from HBsAg+ donors. Using the United Network for Organ Sharing registry, we identified HBsAg+ donors used for LT from 2009 to 2020. We used Kaplan-Meier survival and Cox proportional hazards regression to compare post-LT survival in hepatitis B virus-negative recipients who utilized HBsAg+ donors to propensity-matched cohorts who utilized other types of donors. From 2009-2020, 70 patients received HBsAg+ livers, and 58 of them did not carry a diagnosis of chronic hepatitis B virus. The 1- and 3-year post-LT survival for hepatitis B virus-negative patients who received livers from HBsAg+ donors were 96.6% and 91.4%, respectively, with no statistical differences compared with patients who received livers from hepatitis C virus viremic donors (96.5%/93.0%, P = .961/.427), donation after cardiac death donors (93.0%/86.0%, P = .651/.598), average-risk donors (89.5%/86.0%, P = 0.264/0.617), and a combination of extended-criteria donors, including donation after cardiac death, donor age over 70, and graft with greater than 30% steatosis (93.0%/91.2%, P = .621/.785). Recipients of HBsAg+ livers have similar post-LT survival compared with those receiving other types of grafts. Increasing the utilization of HBsAg+ livers could safely expand the donor pool.
Keywords
Humans, United States, Hepatitis B Surface Antigens, Hepatitis B, Chronic, Liver Transplantation, Hepatitis B virus, Tissue Donors, Hepatitis B, Graft Survival
Published Open-Access
yes
Recommended Citation
Bhatnagar, Anshul; Prakash, Sameer; Lymberopoulos, Peter; et al., "Transplanting Hepatitis B Surface Antigen-Positive Livers in the United States: Outcomes and Opportunities" (2023). Faculty and Staff Publications. 4582.
https://digitalcommons.library.tmc.edu/baylor_docs/4582