Language
English
Publication Date
7-5-2025
Journal
npj Precision Oncology
DOI
10.1038/s41698-025-01029-x
PMID
40617938
PMCID
PMC12228711
PubMedCentral® Posted Date
7-5-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Molecular correlates of cancer patient overall survival (OS) can provide new insights. Here, we systematically cataloged pan-cancer, multi-omic correlates of OS transcending tumor lineage across 11,019 patients, involving multiple cancer types while correcting for cancer-type-intrinsic OS differences. Significant fractions of genes with mRNA associated with OS in pan-cancer analyses showed concordant associations at the levels of DNA copy number alteration or methylation. Pan-cancer gene signatures of T-cell and macrophage tumor infiltrates were associated with better and worse OS, respectively. Pathways implicated by molecular OS associations included metabolism, PI3K/Akt, Wnt, and TGF-beta receptor. Significant fractions of worse OS-associated genes were essential for cell growth. A pan-cancer RNA signature of aggressive cancers associated with greater sensitivity in vitro to inhibitors of MEK1/2, glycolysis pathway, and HSP90, and with chemotherapy response in patient breast tumors. With therapeutic implications, pan-cancer molecular associations with patient survival reveal genes and pathways underlying more aggressive diseases.
Published Open-Access
yes
Recommended Citation
Yiqun Zhang, Fengju Chen, and Chad J Creighton, "Pan-Cancer, Multi-Omic Correlates of Survival Transcending Tumor Lineage Across 11,019 Patients Reveal Targets and Pathways" (2025). Faculty and Staff Publications. 4603.
https://digitalcommons.library.tmc.edu/baylor_docs/4603