Publication Date
1-1-2020
Journal
JBJS Open Access
DOI
10.2106/JBJS.OA.19.00079
PMID
32803102
PMCID
PMC7386545
PubMedCentral® Posted Date
6-26-2020
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Abstract
BACKGROUND: There is a need for novel skin antiseptic agents to combat the health-care burdens associated with surgical site infection (SSI) and bacterial resistance. The purpose of this proof-of-principle pilot study was to investigate the potential of the phenolic compound protocatechuic acid (PCA) as a topical antimicrobial for surgical skin antisepsis.
METHODS: The Kirby-Bauer method of disc diffusion was used to investigate the in vitro antimicrobial activity and comparative effectiveness of PCA and 7 related compounds against SSI pathogens. To explore the in vivo efficacy of topical PCA for providing deep, penetrating skin antisepsis, living
RESULTS: Compared with other polyphenols, PCA demonstrated the broadest spectrum of antimicrobial activity against tested SSI pathogens, including drug-resistant organisms. At 96 hours following infection, the mean
CONCLUSIONS: PCA demonstrated laboratory efficacy against pathogens implicated in SSI, including drug-resistant organisms. In vivo, topical PCA demonstrated dose-dependent skin penetration and antimicrobial activity against mouse skin
CLINICAL RELEVANCE: Topical PCA may have the potential to improve current shoulder SSI treatment and prevention protocols.