Language
English
Publication Date
4-1-2025
Journal
Journal of Clinical Investigation
DOI
10.1172/JCI191423
PMID
40166935
PMCID
PMC11957686
PubMedCentral® Posted Date
4-1-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) remain elusive. In this issue of the JCI, Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon γ release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type alveolar macrophages with a stronger ex vivo response to the pathogen. Studies in these rare individuals, termed "TB resisters" and in tuberculosis household contacts who are repeatedly IGRA negative in the months after a specific exposure event (known as "early clearers") help elucidate manipulatable mechanisms to boost protection against Mtb infection.
Keywords
Humans, Mycobacterium tuberculosis, Tuberculosis, Phenotype, Tuberculin Test, Macrophages, Alveolar, Interferon-gamma Release Tests, HIV Infections
Published Open-Access
yes
Recommended Citation
Setiabudiawan, Todia P; Hill, Philip C; DiNardo, Andrew R; et al., "Insights Into Protection Against Mycobacterium tuberculosis Infection: Time To Officially Confirm Another Phenotype?" (2025). Faculty and Staff Publications. 4687.
https://digitalcommons.library.tmc.edu/baylor_docs/4687