Language

English

Publication Date

5-1-2024

Journal

Current Opinion in Nephrology and Hypertension

DOI

10.1097/MNH.0000000000000976

PMID

38411162

PMCID

PMC11126299

PubMedCentral® Posted Date

5-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

PURPOSE OF REVIEW: Diabetic kidney disease continues to increase, and several novel therapeutic agents have been shown to slow the progression of chronic kidney disease in those with diabetes. This review summarizes more recent data on the role of glucagon-like peptide-1 (GLP-1) receptor agonists and kidney outcomes.

RECENT FINDINGS: Posthoc analysis of cardiovascular outcome trials, as well as several retrospective studies, demonstrate benefits of GLP-1 receptor agonist therapy for chronic kidney disease progression in diabetics. Although limited randomized clinical trials evidence assessing the effects of GLP-1 receptor agonists on kidney outcomes in diabetic chronic kidney disease patients have been published, FLOW-CKD trial was halted based on interim data for efficacy, and results are awaited.

SUMMARY: GLP-1 receptor agonism is a promising therapy for slowing the progression of diabetic chronic kidney disease. Recent studies support kidney benefits GLP-1 receptor agonists over insulin and dipeptidyl peptidase-4-inhibitors, and the FLOW-CKD trial would inform the potential benefits for reducing the need for dialysis and kidney-disease related mortality in those with kidney disease.

Keywords

Humans, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Glucagon-Like Peptide 1, Hypoglycemic Agents, Randomized Controlled Trials as Topic, Renal Dialysis, Renal Insufficiency, Chronic, Retrospective Studies, Glucagon-Like Peptide-1 Receptor Agonists, diabetic kidney disease, GLP-1 receptor agonists, cardiovascular disease

Published Open-Access

yes

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