Language
English
Publication Date
8-8-2025
Journal
Science Advances
DOI
10.1126/sciadv.adw1358
PMID
40768585
PMCID
PMC12327454
PubMedCentral® Posted Date
8-6-2025
PubMedCentral® Full Text Version
Post-print
Abstract
This study investigates a dual-acting drug delivery system using naringenin (NAR) as a folate receptor ligand to enhance intestinal uptake and encapsulated NAR for combating inflammation. The dual-acting systems were tested in vitro on cisplatin-induced human kidney-2 cells and in vivo in a mouse model of cisplatin-induced acute kidney injury (AKI). NAR-loaded passive nanoparticles [P2Ns(NAR)] and dual-acting systems [P2Ns-NAR(NAR)] showed notable advantages over unformulated NAR, reducing the required dose by up to 57 and 79%, respectively. These nanoparticles modulated immune responses, restored T cell function, and shifted macrophage polarization from proinflammatory M1 to tissue-repairing M2. In addition, P2Ns-NAR(NAR) alleviated AKI by reducing fibrosis and lowering Toll-like receptor 4 and nuclear factor κB levels in the kidneys. Notably, P2Ns-NAR(NAR) outperformed other formulations, providing a 50% lower effective dose. This study emphasizes the potential of NAR to overcome intestinal barriers and highlights the importance of polymer functionality in delivering effective treatments for inflammatory diseases.
Keywords
Animals, Nanoparticles, Humans, Mice, Polyesters, Anti-Inflammatory Agents, Acute Kidney Injury, Disease Models, Animal, Cisplatin, Cell Line, Flavanones, Drug Delivery Systems, Macrophages, Toll-Like Receptor 4, Inflammation, Kidney, NF-kappa B
Published Open-Access
yes
Recommended Citation
Heyns, Ingrid M; Wahab, Abiodun T; Ganugula, Raghu; et al., "Dual-Function Polyester Nanoparticles for Amplified Anti-inflammatory Effects" (2025). Faculty and Staff Publications. 4735.
https://digitalcommons.library.tmc.edu/baylor_docs/4735