Language
English
Publication Date
12-1-2022
Journal
Bone Reports
DOI
10.1016/j.bonr.2022.101641
PMID
36466709
PMCID
PMC9713281
PubMedCentral® Posted Date
11-24-2022
PubMedCentral® Full Text Version
Post-print
Abstract
Long considered an inert supporting framework, bone studies went neglected until the 17th century when they began as descriptive microscopic studies of structure which over time progressed into that of chemistry and physiology. It was in the mid-19th century that studies evolved into an inquisitive discipline which matured into the experimental investigation of bone in health and disease in the 20th century, and ultimately that of molecular studies now deciphering the genetic language of bone biology. These fundamental studies were catalyzed by increasing clinical interest in bone disease. The first bone disease to be identified was rickets in 1645. Its subsequent connection to albuminuric patients reported in 1883 later became renal osteodystrophy in 1942, launching studies that elucidated the functions of vitamin D and parathyroid hormone and their role in the altered calcium and phosphate metabolism of the disease. Studies in osteoporosis and renal osteodystrophy have driven most recent progress benefitting from technological advances in imaging and the precision of evaluating bone turnover, mineralization, and volume. This review exposes the progress of bone biology from a passive support structure to a dynamically regulated organ with vital homeostatic functions whose understanding has undergone more revisions and paradigm shifts than that of any other organ.
Keywords
Renal osteodystrophy, Rickets, Osteoporosis, CKD-MBD, Bone
Published Open-Access
yes
Recommended Citation
Garabed Eknoyan and Sharon M Moe, "Renal Osteodystrophy: A Historical Review of Its Origins and Conceptual Evolution" (2022). Faculty and Staff Publications. 4739.
https://digitalcommons.library.tmc.edu/baylor_docs/4739