Language
English
Publication Date
1-18-2024
Journal
Thorax
DOI
10.1136/thorax-2023-220022
PMID
38071573
PMCID
PMC10911453
PubMedCentral® Posted Date
1-18-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well as ageing and lifestyle factors such as smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) in individuals with rheumatoid arthritis (RA). This is the largest study to demonstrate and replicate that shortened peripheral blood leukocytes-TL is associated with ILD in patients with RA compared with RA without ILD in a multinational cohort, and short PBL-TL was associated with baseline disease severity in RA-ILD as measured by forced vital capacity percent predicted.
Keywords
Humans, Telomere Shortening, Telomere, Arthritis, Rheumatoid, Lung Diseases, Interstitial, Smoking, Telomere length, Rheumatoid arthritis, Interstitial lung disease, 9.23 Interstitial Lung Disease
Published Open-Access
yes
Recommended Citation
Doyle, Tracy J; Juge, Pierre-Antoine; Peljto, Anna L; et al., "Short Peripheral Blood Leukocyte Telomere Length in Rheumatoid Arthritis-Interstitial Lung Disease" (2024). Faculty and Staff Publications. 4742.
https://digitalcommons.library.tmc.edu/baylor_docs/4742
Included in
Critical Care Commons, Health Services Research Commons, Medical Sciences Commons, Pulmonology Commons, Sleep Medicine Commons