Liposomes as Imaging Agents of Inflammation and Oxidative Stress in Bone Implants

Authors

Delia Danila
Patricia S Pardo
R Devesh Kumar Misra
Aladin M Boriek

Language

English

Publication Date

4-22-2025

Journal

Current Issues in Molecular Biology

DOI

10.3390/cimb47050295

PMID

40699694

PMCID

PMC12109971

PubMedCentral® Posted Date

4-22-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Liposomes are tiny, spherical vesicles made from cholesterol and natural phospholipids that are promising imaging agents for detecting medical complications. They can carry fluorescent markers or other imaging agents, making them effective for medical imaging. Furthermore, liposomes can target specific cells involved in inflammation, such as macrophages, and accumulate at inflammation sites when injected. Additionally, liposomes can be designed to respond to oxidative stress, which is often associated with bone implant complications. By detecting areas of stress, liposomes provide valuable information about implant health. However, challenges such as rapid clearance from the body, precise targeting, immune reactions, and high production costs must be addressed. Research is ongoing to improve the design and functionality of liposomes. They can potentially monitor bone implants as non-invasive imaging agents, enabling early detection of complications and timely interventions. This approach can enhance patient outcomes and extend the longevity of implants, making it a promising strategy for better patient care and implant success.

Keywords

liposomes, non-invasive imaging agents, bone-implant complications, inflammation, oxidative stress, bioimaging

Published Open-Access

yes

Recommended Citation

Danila, Delia; Pardo, Patricia S; Misra, R Devesh Kumar; et al., "Liposomes as Imaging Agents of Inflammation and Oxidative Stress in Bone Implants" (2025). Faculty and Staff Publications. 4768.
https://digitalcommons.library.tmc.edu/baylor_docs/4768