Gut Dysbiosis Patterns in Cvid Patients With Noninfectious Complications Observed in a Germ-Free Mouse Model Through Fecal Microbiota Transplantation

Authors

Joud Hajjar
Anita Y Voigt
Margaret E Conner
Alton G Swennes
Stephanie Fowler
Chadi Calarge
Danielle D Mendonca
Dominique Armstrong
Chen-Yen Chang
Jolan E Walter
Manish J Butte
Tor Savidge
Julia Oh
Farrah Kheradmand
Joseph F Petrosino

Language

English

Publication Date

5-5-2025

Journal

Journal of Human Immunity

DOI

10.70962/jhi.20250040

PMID

41019955

PMCID

PMC12462835

PubMedCentral® Posted Date

9-26-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Patients with common variable immunodeficiency (CVID) who develop noninfectious complications (NIC) have worse clinical outcomes than those with infections only (INF). While gut microbiome aberrations have been linked to NIC, reductionist animal models that accurately recapitulate CVID are lacking. Our aim in this study was to uncover potential microbiome roles in the development of NIC in CVID. We performed whole-genome shotgun sequencing on fecal samples from CVID patients with NIC, INF, and their household controls. We also performed fecal microbiota transplants from CVID patients to germ-free mice. We found potentially pathogenic microbes

Published Open-Access

yes

Recommended Citation

Hajjar, Joud; Voigt, Anita Y; Conner, Margaret E; et al., "Gut Dysbiosis Patterns in Cvid Patients With Noninfectious Complications Observed in a Germ-Free Mouse Model Through Fecal Microbiota Transplantation" (2025). Faculty and Staff Publications. 4780.
https://digitalcommons.library.tmc.edu/baylor_docs/4780