Language
English
Publication Date
1-1-2023
Journal
Microbiota and Host
DOI
10.1530/mah-23-0012
PMID
38957594
PMCID
PMC11219018
PubMedCentral® Posted Date
7-2-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
The epithelial lining of the small intestine mediates its absorptive and secretory function and thus is a critical component of human health. Regeneration and renewal of the epithelium is the result of proliferation of intestinal stem cells (ISCs). Many cell types and molecular factors are known to regulate the ability of ISCs to proliferate, including adjacent neighboring epithelial cells and the underlying, supportive stromal cells. The microbiome resides in the lumen of the small intestine and is in close contact with the epithelium. Due to its proximity to ISCs, it has been hypothesized that species within the microbiome have the capacity to regulate ISC proliferation and differentiation. This review highlights research that probes interactions between ISCs and the microbiome in the small intestine to detail the current understanding of microbial regulation of ISCs. Results from these studies provide important knowledge that can be exploited to identify therapeutic targets or develop novel preventative treatments to treat intestinal diseases.
Published Open-Access
yes
Recommended Citation
Victoria Poplaski, Faith Sawyer, and Sarah E Blutt, "The Small Intestinal Microbiome: Vibing With Intestinal Stem Cells" (2023). Faculty and Staff Publications. 4812.
https://digitalcommons.library.tmc.edu/baylor_docs/4812
Included in
Health Services Research Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Virology Commons