Publication Date
2-1-2024
Journal
Cureus
DOI
10.7759/cureus.54127
PMID
38487135
PMCID
PMC10939161
PubMedCentral® Posted Date
2-13-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
derm path, non-malignant hematology, hydroxyurea use, non-healing ulcer, sickle cell disease complications
Abstract
Sickle cell disease is a condition that can involve numerous organ systems secondary to vascular occlusion. Herein, we present a case of a 21-year-old male with sickle cell disease requiring long-term hydroxyurea therapy. Upon migrating to the United States from Yemen, the patient developed a rapidly progressive, exquisitely painful ulcer on his right lower extremity. Given his country of origin, a broad differential, including select infectious diseases, was essential. Moreover, establishing the unequivocally correct diagnosis was crucial to determine proper and safe therapy. Ultimately, a lesional biopsy demonstrated numerous sickled red blood cells occluding blood vessels, leading to the diagnosis of sickle cell disease-related leg ulceration.
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, Dermatology Commons, Hematology Commons, Hemic and Lymphatic Diseases Commons, Medical Cell Biology Commons, Medical Immunology Commons, Skin and Connective Tissue Diseases Commons