Publication Date

2-1-2024

Journal

Cureus

DOI

10.7759/cureus.54127

PMID

38487135

PMCID

PMC10939161

PubMedCentral® Posted Date

2-13-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

derm path, non-malignant hematology, hydroxyurea use, non-healing ulcer, sickle cell disease complications

Abstract

Sickle cell disease is a condition that can involve numerous organ systems secondary to vascular occlusion. Herein, we present a case of a 21-year-old male with sickle cell disease requiring long-term hydroxyurea therapy. Upon migrating to the United States from Yemen, the patient developed a rapidly progressive, exquisitely painful ulcer on his right lower extremity. Given his country of origin, a broad differential, including select infectious diseases, was essential. Moreover, establishing the unequivocally correct diagnosis was crucial to determine proper and safe therapy. Ultimately, a lesional biopsy demonstrated numerous sickled red blood cells occluding blood vessels, leading to the diagnosis of sickle cell disease-related leg ulceration.

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