Language
English
Publication Date
11-1-2023
Journal
American Journal of Physiology - Gastrointestinal and Liver Physiology
DOI
10.1152/ajpgi.00090.2023
PMID
37697947
PMCID
PMC10812707
PubMedCentral® Posted Date
9-12-2023
PubMedCentral® Full Text Version
Post-print
Abstract
The liver plays a significant role in regulating a wide range of metabolic, homeostatic, and host-defense functions. However, the impact of liver injury on the host's ability to control bacteremia and morbidity in sepsis is not well understood. Leukocyte recruitment and activation lead to cytokine and chemokine release, which, in turn, trigger hepatocellular injury and elevate nucleotide levels in the extracellular milieu. P2Y2 purinergic receptors, G protein-coupled and activated by extracellular ATP/UTP, are expressed at the cell surface of hepatocytes and nonparenchymal cells. We sought to determine whether P2Y2 purinergic receptor function is necessary for the maladaptive host response to bacterial infection and endotoxin-mediated inflammatory liver injury and mortality in mice. We report that P2Y2 purinergic receptor knockout mice (P2Y2
Keywords
Mice, Animals, Lipopolysaccharides, Gene Deletion, Lbacteremia, inflammation, liver injury, P2Y2 purinergic receptor, sepsisiver, Cytokines, Sepsis, Bacterial Infections, Bacteremia, Nucleotides, Arginine, Receptors, Purinergic, Amino Acids, Mice, Inbred C57BL, Receptors, Purinergic P2Y2, Mice, Knockout
Published Open-Access
yes
Recommended Citation
Arunachalam, Athis R; Samuel, Sanju S; Mani, Arunmani; et al., "P2Y2 Purinergic Receptor Gene Deletion Protects Mice From Bacterial Endotoxin and Sepsis-Associated Liver Injury and Mortality" (2023). Faculty and Staff Publications. 4893.
https://digitalcommons.library.tmc.edu/baylor_docs/4893
Graphical Abstract
Included in
Health Services Research Commons, Hepatology Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Microbiology Commons