Language
English
Publication Date
7-1-2025
Journal
PLoS Biology
DOI
10.1371/journal.pbio.3003299
PMID
40658744
PMCID
PMC12273945
PubMedCentral® Posted Date
7-14-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Metastasis is the predominant cause of cancer mortality, primarily driven by complex tumor-host interactions within specialized metastatic niches. Recent advances in single-cell technologies have provided unprecedented insights into metastatic niche formation, evolution and function, including how primary tumors precondition distant organs for metastases and how disseminated tumor cells dynamically interact with host cells to modulate their environments. Integrated single-cell studies across multiple cancer types have also revealed divergent and convergent metastatic adaptation strategies. These findings collectively highlight metastasis as a dynamic, cooperative process shaped by intricate tumor-host interactions, and provide a foundation for novel therapeutic strategies targeting components of the metastatic microenvironment.
Keywords
Animals, Humans, Neoplasm Metastasis, Neoplasms, Single-Cell Analysis, Tumor Microenvironment
Published Open-Access
yes
Recommended Citation
Fengshuo Liu and Xiang H-F Zhang, "Decoding Metastatic Microenvironments Through Single-Cell Omics Reveals New Insights Into Niche Dynamics and Tumor Evolution" (2025). Faculty and Staff Publications. 4907.
https://digitalcommons.library.tmc.edu/baylor_docs/4907
Included in
Health Services Research Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Microbiology Commons