Language

English

Publication Date

7-16-2025

Journal

Scientific Reports

DOI

10.1038/s41598-025-08538-6

PMID

40670446

PMCID

PMC12267855

PubMedCentral® Posted Date

7-16-2025

PubMedCentral® Full Text Version

Post-print

Abstract

The dynamics of neural circuits and their role in mediating cellular and organismal phenomena remain poorly understood, despite numerous efforts to dissect these processes through precise instantaneous measurements or longer-time averages and approximations. We use an alternative approach: we investigate these dynamics at the system's mesoscale by analyzing spike trains and waveforms. These extended activity patterns carry robust, tractable information, are highly responsive to physiological specifics, and enable detailed tracking of circuit behavior. In particular, this methodology allows for characterizing the functionality of tau-pathology-afflicted hippocampal circuits and identifying circuit-level abnormalities that are missed by through traditional analyses. In healthy mice, spike flows and field undulations exhibit strong coupling with the animal's location, speed, and acceleration. In contrast, neural activity in tau-mice is profoundly disorganized: brainwave cadence becomes decoupled from locomotion, spatial selectivity is lost, and spike flow is disrupted. Importantly, these alterations emerge early and progressively worsen with age, revealing a gradual dissociation of the hippocampal circuit from spatial behavior.

Keywords

Animals, Mice, Hippocampus, Neurons, Action Potentials, tau Proteins, Mice, Transgenic, Male, Nerve Net, Computational biology and bioinformatics, Neuroscience, Computational neuroscience, Neural decoding

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.