Language
English
Publication Date
10-1-2024
Journal
American Journal of Physiology - Endocrinology and Metabolism
DOI
10.1152/ajpendo.00154.2024
PMID
39140971
Abstract
Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies. The pivotal role of PNNs in the context of energy balance and whole body blood glucose is examined. This review also highlights novel findings, including the effects of astroglia, microglia, sex and gonadal hormones, nutritional regulation, circadian rhythms, and age on PNNs dynamics. These findings illuminate the complex and multifaceted role of PNNs in metabolic health.
Keywords
Humans, Extracellular Matrix, Animals, Energy Metabolism, Neurons, Circadian Rhythm, Microglia, Astrocytes, blood glucose, energy balance, metabolism, perineuronal nets
Published Open-Access
yes
Recommended Citation
Zhang, Nan; Song, Beite; Bai, Peng; et al., "Perineuronal Nets’ Role in Metabolism" (2024). Faculty and Staff Publications. 4929.
https://digitalcommons.library.tmc.edu/baylor_docs/4929
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Health Services Research Commons, Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Specialties Commons, Microbiology Commons