Language
English
Publication Date
10-30-2025
Journal
Cell
DOI
10.1016/j.cell.2025.10.008
PMID
41172998
Abstract
The female Aedes aegypti mosquito's remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Aedes aegypti Mosquito Cell Atlas, a comprehensive single-nucleus RNA sequencing dataset of more than 367,000 nuclei from 19 dissected tissues of adult female and male Aedes aegypti, providing cellular-level resolution of mosquito biology. We identify novel cell types and expand our understanding of sensory neuron organization of chemoreceptors across all sensory tissues. Our analysis uncovers male-specific cells and sexually dimorphic gene expression in the antenna and brain. In female mosquitoes, we find that glial cells, rather than neurons, undergo the most extensive transcriptional changes in the brain following blood feeding. Our findings provide insights into the cellular basis of mosquito behavior and sexual dimorphism. The Aedes aegypti Mosquito Cell Atlas resource enables systematic investigation of cell-type-specific expression across all mosquito tissues.
Keywords
Aedes aegypti. cell atlas. mosquito. sexual dimorphism. snRNA-seq.
Published Open-Access
yes
Recommended Citation
Goldman, Olivia V; DeFoe, Alexandra E; Qi, Yanyan; et al., "A Single-Nucleus Transcriptomic Atlas of the Adult Aedes aegypti Mosquito" (2025). Faculty and Staff Publications. 5051.
https://digitalcommons.library.tmc.edu/baylor_docs/5051
Included in
Genetic Phenomena Commons, Genetic Processes Commons, Genetic Structures Commons, Medical Genetics Commons, Medical Molecular Biology Commons, Medical Specialties Commons