Language
English
Publication Date
10-1-2024
Journal
International Journal of Hematology
DOI
10.1007/s12185-024-03789-x
PMID
38750343
PMCID
PMC11779507
PubMedCentral® Posted Date
1-29-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targeting the aberrant metabolism in LSCs. Dysregulated metabolism is involved in sustaining functional properties of LSCs, impeding myeloid differentiation, and evading programmed cell death, both in the process of leukemogenesis and in response to chemotherapy. This review discusses recent discoveries regarding the aberrant metabolic processes of AML LSCs that have begun to change the therapeutic landscape of AML.
Keywords
Humans, Leukemia, Myeloid, Acute, Neoplastic Stem Cells, Animals, Cell Differentiation, Drug Resistance, Neoplasm, acute myeloid leukemia, leukemia stem cell, metabolic regulation
Published Open-Access
yes
Recommended Citation
Xiangguo Shi, Mengdie Feng, and Daisuke Nakada, "Metabolic Dependencies of Acute Myeloid Leukemia Stem Cells" (2024). Faculty and Staff Publications. 5078.
https://digitalcommons.library.tmc.edu/baylor_docs/5078
Included in
Genetic Phenomena Commons, Genetic Processes Commons, Genetic Structures Commons, Medical Genetics Commons, Medical Molecular Biology Commons, Medical Specialties Commons