Language
English
Publication Date
11-20-2025
Journal
Communications Biology
DOI
10.1038/s42003-025-08805-2
PMID
41266782
PMCID
PMC12635067
PubMedCentral® Posted Date
11-20-2025
PubMedCentral® Full Text Version
Post-print
Abstract
The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impact. In this work we discover previously uncharacterized genomic dynamics in 18 cells from three human brains utilizing single cell long-read whole genome sequencing. This provides key insights into the dynamic of the genomes of individual cells and further highlights brain specific activity of transposable elements, but requires validation in larger studies.
Keywords
Humans, DNA Transposable Elements, Single-Cell Analysis, Brain, Whole Genome Sequencing, Genome, Human, Genome informatics, DNA sequencing, Movement disorders
Published Open-Access
yes
Recommended Citation
Izydorczyk, Michal B; Kalef-Ezra, Ester; Horner, Dominic W; et al., "Single Cell Long Read Whole Genome Sequencing Reveals Somatic Transposon Activity in Human Brain" (2025). Faculty and Staff Publications. 5114.
https://digitalcommons.library.tmc.edu/baylor_docs/5114
Included in
Genetic Phenomena Commons, Genetic Processes Commons, Genetic Structures Commons, Medical Genetics Commons, Medical Molecular Biology Commons, Medical Specialties Commons