Language
English
Publication Date
1-17-2025
Journal
Clinical Cancer Research
DOI
10.1158/1078-0432.CCR-24-1947
PMID
39540884
PMCID
PMC11747828
PubMedCentral® Posted Date
7-17-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex are rare conditions, which each increases risk for distinct spectra of benign and malignant neoplasms throughout childhood and adulthood. Surveillance considerations for each of these conditions focus on patient and family education, early detection, and multidisciplinary care. In this article, we present updated surveillance recommendations and considerations for children and adolescents with phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex and provide suggestions for further research in each of these conditions.
Keywords
Humans, Ribonuclease III, Tuberous Sclerosis, Hamartoma Syndrome, Multiple, DEAD-box RNA Helicases, Child, Genetic Predisposition to Disease, PTEN Phosphohydrolase, Adolescent, Mutation, PTEN; PTEN hamartoma tumor syndrome (PHTS); DICER1; DICER1 tumor predisposition; tuberous sclerosis complex ((TSC), TSC1, TSC2); cancer surveillance; pediatric cancer predisposition; cancer risk
Published Open-Access
yes
Recommended Citation
Schultz, Kris Ann P; MacFarland, Suzanne P; Perrino, Melissa R; et al., "Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex" (2025). Faculty and Staff Publications. 5194.
https://digitalcommons.library.tmc.edu/baylor_docs/5194
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