Language
English
Publication Date
6-18-2025
Journal
Neuron
DOI
10.1016/j.neuron.2025.03.016
PMID
40267911
PMCID
PMC12410895
PubMedCentral® Posted Date
9-5-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
The brain's endocannabinoid signaling system modulates a diverse range of physiological phenomena and is also involved in various psychiatric and neurological disorders. The basic components of the molecular machinery underlying endocannabinoid-mediated synaptic signaling have been known for decades. However, limitations associated with the short-lived nature of endocannabinoid lipid signals had made it challenging to determine the spatiotemporal specificity and dynamics of endocannabinoid signaling in vivo. Here, we discuss how novel technologies have recently enabled unprecedented insights into endocannabinoid signaling taking place at specific synapses in behaving animals. In this review, we primarily focus on cannabinoid-sensitive inhibition in the hippocampus in relation to place cell properties to illustrate the potential of these novel methodologies. In addition, we highlight implications of these approaches and insights for the unraveling of cannabinoid regulation of synapses in vivo in other brain circuits in both health and disease.
Keywords
Animals, Endocannabinoids, Hippocampus, Interneurons, Signal Transduction, Cholecystokinin, Behavior, Animal, Nerve Net
Published Open-Access
yes
Recommended Citation
Malhotra, Shreya; Donneger, Florian; Farrell, Jordan S; et al., "Integrating Endocannabinoid Signaling, CCK Interneurons, and Hippocampal Circuit Dynamics in Behaving Animals" (2025). Faculty and Staff Publications. 5275.
https://digitalcommons.library.tmc.edu/baylor_docs/5275