Language
English
Publication Date
12-4-2025
Journal
Epilepsy Currents
DOI
10.1177/15357597251404966
PMID
41357743
PMCID
PMC12678142
PubMedCentral® Posted Date
12-4-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high-frequency oscillations (HFOs >250 Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS. Methods: Wideband (0.1 to 500 Hz, 2048 Hz) polysomnography was performed using the international 10–20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review. Results: Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs. HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases. A trend toward increasing HFO rates with age in DS warrants further confirmation. Discussion: HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.
Published Open-Access
yes
Recommended Citation
Manuel Silva-Pérez and Jeannie Chin, "Super-Fast, Super-Early: High-Frequency Oscillations May Be a Prelude to Alzheimer's Dementia in Down Syndrome" (2025). Faculty and Staff Publications. 5292.
https://digitalcommons.library.tmc.edu/baylor_docs/5292