Publication Date
1-1-2024
Journal
Imaging Neuroscience
DOI
10.1162/imag_a_00311
PMID
40656773
PMCID
PMC12254000
PubMedCentral® Posted Date
10-15-2024
PubMedCentral® Full Text Version
Post-print
Abstract
A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive and negative BOLD responses. Here, we present an innovative multi-contrast laminar functional MRI technique that offers comprehensive and quantitative imaging of neurovascular (CBF, CBV, BOLD) and metabolic (CMRO2) responses across cortical layers at 7T. This technique was first validated through a finger-tapping experiment, revealing ‘double-peak’ laminar activation patterns within the primary motor cortex. By employing a ring-shaped visual stimulus that elicited positive and negative BOLD responses, we further observed distinct neurovascular and metabolic responses across cortical layers and eccentricities in the primary visual cortex. This suggests potential feedback inhibition of neuronal activities in both superficial and deep cortical layers underlying the negative BOLD signals in the fovea, and also illustrates the neuronal activities in visual areas adjacent to the activated eccentricities.
Keywords
mesoscopic fMRI, muti-contrast fMRI, arterial spin labeling, VASO, negative BOLD, ultra-high field (UHF)
Published Open-Access
yes
Recommended Citation
Shao, Xingfeng; Guo, Fanhua; Kim, JungHwan; et al., "Laminar Multi-Contrast fMRI at 7T Allows Differentiation of Neuronal Excitation and Inhibition Underlying Positive and Negative Bold Responses" (2024). Faculty and Staff Publications. 5309.
https://digitalcommons.library.tmc.edu/baylor_docs/5309