Language
English
Publication Date
10-29-2025
Journal
Molecular Neurodegeneration
DOI
10.1186/s13024-025-00905-1
PMID
41163155
PMCID
PMC12570858
PubMedCentral® Posted Date
10-29-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Microglia are the resident immune cell of the brain, and alterations in microglia signaling have been implicated in many neurodegenerative disorders. While microglia responses to central cues and other brain cell types are well documented, studies are increasingly investigating the impact of peripherally derived signals on microglia function. A diverse array of peripheral cues, including dietary components, hormones, and bacteria metabolites and components from the microbiome cross the blood brain barrier and directly influence microglia state through ligand-receptor interactions. This review highlights the complexity of brain-body interactions from the perspective of microglia function and proposes the idea that microglia could serve as a central hub of detection and regulation of body state changes. In addition, improving understanding of how microglia respond to peripheral cues will allow for improved preclinical experimental design. As peripheral cues have the potential to be more readily manipulated than central cues, these interactions also have implications for the treatment of many diseases and neurodegenerative disorders.
Keywords
Humans, Microglia, Animals, Brain, Signal Transduction, Neurodegenerative Diseases, Blood-Brain Barrier, Microglia, Central nervous system, Peripheral cues, Neurodegenerative disease, Neurons
Published Open-Access
yes
Recommended Citation
Claire E Young and Melanie A Samuel, "Microglia Sensing of Peripheral Signals That Bridge the Brain and Body" (2025). Faculty and Staff Publications. 5314.
https://digitalcommons.library.tmc.edu/baylor_docs/5314
Graphical Abstract