Publication Date
12-1-2025
Journal
eLife
DOI
10.7554/eLife.107012
PMID
41324261
PMCID
PMC12668672
PubMedCentral® Posted Date
12-1-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Despite their importance for brain function, cortico-subcortical white matter tracts are under-represented in diffusion magnetic resonance imaging tractography studies. Their non-invasive mapping is more challenging and less explored compared to other major cortico-cortical bundles. We introduce a set of standardised tractography protocols for delineating tracts between the cortex and various deep subcortical structures, including the caudate, putamen, amygdala, thalamus, and hippocampus. To enable comparative studies, our protocols are designed for both human and macaque brains. We demonstrate how tractography reconstructions follow topographical principles obtained from tracers in the macaque and how these translate to humans. We show that the proposed protocols are robust against data quality and preserve aspects of individual variability stemming from family structure in humans. Lastly, we demonstrate the value of these species-matched protocols in mapping homologous grey matter regions in humans and macaques, both in cortex and subcortex.
Keywords
Animals, Humans, Diffusion Tensor Imaging, Macaca, White Matter, Brain Mapping, Cerebral Cortex, Gray Matter, Male
Published Open-Access
yes
Recommended Citation
Assimopoulos, Stephania; Warrington, Shaun; Folloni, Davide; et al., "Cross-Species Standardised Cortico-Subcortical Tractography" (2025). Faculty and Staff Publications. 5376.
https://digitalcommons.library.tmc.edu/baylor_docs/5376