Publication Date
1-1-2024
Journal
Journal of Cardiology
DOI
10.5603/CJ.a2022.0014
PMID
35373328
PMCID
PMC11076033
PubMedCentral® Posted Date
4-26-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pancreatic Neoplasms, Risk Factors, Risk Assessment, Incidence, Protective Factors, pancreatic cancer, pancreatic malignancy, statin, risk, systematic review, meta-analysis
Abstract
BACKGROUND: Statin use in many studies is related to the improvement of a patients' condition including reducing the risk of various malignancies. Herein, is a systematic review and meta-analysis to examine the evidence on the association between statin therapy and the risk of the occurrence of pancreatic cancer, mainly in terms of decreased risk of developing pancreatic cancer among patients using statin therapy in the long-term perspective.
METHODS: PubMed, Web of Science, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to December 1st, 2021. Random effect models were used to estimate summary odds ratios (OR) and the corresponding 95% confidence intervals (CI).
RESULTS: A total of 26 studies comprising 2,797,186 patients were included. Polled analysis showed that pancreatic cancer occurrence in statin vs. no-statin group varied and amounted to 0.4% vs. 0.6% (RR = 0.83; 95% CI: 0.72-0.96; I² = 84%; p = 0.01).
CONCLUSIONS: In summary, the present analysis shows that overall statins use is significantly associated with a reduction in risk of pancreatic cancer. However, these results were not confirmed for the randomized controlled trial subgroup. Further prospective studies are needed to confirm the current results.
Included in
Digestive System Diseases Commons, Emergency Medicine Commons, Gastroenterology Commons, Medical Sciences Commons, Oncology Commons
Comments
Associated Data