Language

English

Publication Date

12-3-2024

Journal

Brain

DOI

10.1093/brain/awae253

PMID

39054600

PMCID

PMC11730443

PubMedCentral® Posted Date

7-26-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as well as further insights from post-mortem imaging, has been highlighted.

Keywords

Humans, Neuroimaging, Brain, Prenatal Diagnosis, Female, Pregnancy, Nervous System Malformations, Magnetic Resonance Imaging, Ultrasonography, Prenatal, malformations of cortical development, neuroimaging, fetal ultrasound, brain, fetal MRI

Published Open-Access

yes

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