Language
English
Publication Date
5-10-2025
Journal
BMC Pregnancy and Childbirth
DOI
10.1186/s12884-025-07558-4
PMID
40349027
PMCID
PMC12066072
PubMedCentral® Posted Date
5-10-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Background: First trimester prediction of fetal growth restriction (FGR) remain suboptimal. We aimed to search for new circulating angiogenic biomarkers for improvement.
Methods: This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11-13 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX® human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.
Results: In the early-onset FGR group, log10MoM of soluble neuropilin-1 (sNRP-1: 0.08 ± 0.11 vs. 0.00 ± 0.09, P < 0.001) and log10MoM of soluble platelet and endothelial cell adhesion molecule 1 (sPECAM-1: 0.05 ± 0.06 vs. 0.00 ± 0.09, P < 0.05) were significantly higher than the control group, while log10MoM of platelet-derived growth factor AB/BB (PDGF-AB/BB: -0.08 ± 0.13 vs. 0.00 ± 0.16, P < 0.05) and PAPP-A (-0.15 ± 0.28 vs. 0.05 ± 0.23, P < 0.001) were lower. Their combination achieved the highest area under the ROC curve (AUC) of 0.83 (95% CI: 0.74-0.95) with a higher sensitivity than that of PAPP-A alone (61.5% vs. 30.8% at 10% false positive rate, P < 0.001). Concerning the late-onset FGR group, only log10MoMs of sFlt-1 (-0.12 vs. 0.00, P < 0.001) and PAPP-A (-0.07 vs. 0.05, P < 0.05) were lower than the control group, but their AUC was only 0.68 (95% CI:0.59-0.78).
Conclusions: Three new first trimester biomarkers, sNRP-1, sPECAM-1 and PDGF-AB/BB are predictive of subsequent development of early-onset FGR.
Keywords
Humans, Female, Pregnancy, Fetal Growth Retardation, Case-Control Studies, Pregnancy Trimester, First, Biomarkers, Adult, ROC Curve, Neuropilin-1, Predictive Value of Tests, Pregnancy-Associated Plasma Protein-A, Platelet Endothelial Cell Adhesion Molecule-1, Angiogenic biomarker, Fetal growth restriction, Platelet-derived growth factor, Placenta growth factor, Pregnancy-associated plasma protein A, Soluble fms-like tyrosine kinase-1, Soluble neuropilin-1, Soluble platelet and endothelial cell adhesion molecule 1
Published Open-Access
yes
Recommended Citation
Bai, Xiaoyi; Li, Wei; Ding, Wenjing; et al., "New First Trimester Circulating Angiogenic Biomarkers in Predicting Early-Onset and Late-Onset Fetal Growth Restriction: A Case-Control Study" (2025). Faculty and Staff Publications. 5472.
https://digitalcommons.library.tmc.edu/baylor_docs/5472