Language

English

Publication Date

12-17-2024

Journal

Journal of Cataract & Refractive Surgery

DOI

10.1097/j.jcrs.0000000000001603

PMID

39682055

PMCID

PMC11980897

PubMedCentral® Posted Date

3-25-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Purpose: To evaluate the ZEISS AI IOL Calculator (ZEISS AI) and compare its accuracy in refractive prediction to the Barrett Universal II (BUII) and Kane formulas.

Setting: Cullen Eye Institute, Baylor College of Medicine, Houston, TX.

Design: Retrospective case series.

Methods: The ZEISS AI IOL Calculator (ZEISS AI) is an artificial intelligence (AI) based IOL-optimized formula. The refractive prediction errors (PEs) were calculated in the entire dataset and subgroups of short eyes (axial length (AL) ≤ 22.5 mm) and long eyes (AL ≥ 25.0 mm). The standard deviation (SD), root-mean-square absolute error (RMSAE), mean absolute error (MAE), median absolute error (MedAE), and percentage of eyes within ±0.25 D, ±0.50 D, ±0.75 D, and ±1.00 D of PEs were calculated. Values with ZEISS AI were compared to those from Barrett Universal II (BUII) and Kane. Advanced statistical methods were applied using R.

Results: A dataset of 10,838 eyes was included. Compared to ZEISS AI, BUII produced significantly greater SDs, RMSAEs, and MAEs in the whole group and short eyes, and the Kane had greater SD, RMSAE, and MAE in short eyes (all adjusted P< 0.05); the BUII had significantly lower percentages of eyes within ±0.50 D of PEs in the whole group (80.0% vs 81.2%) and in short eyes (71.3% vs. 76.1%), and the Kane had lower percentage of eyes within ±0.50 D of PEs in short eyes (71.9% vs. 76.1%) (all adjusted P< 0.05).

Conclusion: The ZEISS AI IOL Calculator had superior performance compared to the BUII and Kane formulas, especially in short eyes.

Published Open-Access

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